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Nucleic Acids Research, 2003, Vol. 31, No. 1 266-269
© 2003 Oxford University Press

PRODORIC: prokaryotic database of gene regulation

Richard Münch1, Karsten Hiller1, Heiko Barg1, Dana Heldt1, Simone Linz1, Edgar Wingender2,3 and Dieter Jahn*,1

1 Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstrasse 7, D-38106 Braunschweig, Germany 2 Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-38124 Braunschweig, Germany 3 BIOBASE GmbH, Halchtersche Strasse 33, D-38304 Wolfenbüttel, Germany

*To whom correspondence should be addressed. Tel: +49 5313915801; Fax: +49 5313915854; Email: d.jahn{at}tu-bs.de

ABSTRACT

The database PRODORIC aims to systematically organize information on prokaryotic gene expression, and to integrate this information into regulatory networks. The present version focuses on pathogenic bacteria such as Pseudomonas aeruginosa. PRODORIC links data on environmental stimuli with trans-acting transcription factors, cis-acting promoter elements and regulon definition. Interactive graphical representations of operon, gene and promoter structures including regulator-binding sites, transcriptional and translational start sites, supplemented with information on regulatory proteins are available at varying levels of detail. The data collection provided is based on exhaustive analyses of scientific literature and computational sequence prediction. Included within PRODORIC are tools to define and predict regulator binding sites. It is accessible at http://prodoric.tu-bs.de.


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