Nucleic Acids Research

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Nucleic Acids Research, 2003, Vol. 31, No. 1 311-314
© 2003 Oxford University Press

IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex

James Robinson¹, Matthew J. Waller¹, Peter Parham³, Natasja de Groot⁴, Ronald Bontrop⁴, Lorna J. Kennedy⁵, Peter Stoehr⁶ and Steven G. E. Marsh^*,1,2

¹ Anthony Nolan Research Institute and Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK ² Department of Haematology, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK ³ Departments of Structural Biology and Microbiology & Immunology, Stanford University, Stanford, CA 94305, USA ⁴ Biomedical Primate Research Centre, Lange Kleiweg 139, Rijswijk, The Netherlands ⁵ Centre for Integrated Genomic Medical Research, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK ⁶ EMBL Outstation, The European Bioinformatics Institute (EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

*To whom correspondence should be addressed. Tel: +44 20 72848321; Fax: +44 20 72848331; Email: marsh{at}ebi.ac.uk

ABSTRACT

The IMGT/HLA database (http://www.ebi.ac.uk/imgt/hla) has provided a centralized repository for the sequences of the alleles named by the WHO Nomenclature Committee for Factors of the HLA System for the past four years. Since its initial release the database has grown and is the primary source of information for the study of sequences of the human major histocompatibilty complex. The initial release of the database contained a limited number of tools. As a result of feedback from our users and developments in HLA we have been able to provide new tools and facilities. The HLA sequences have also been extended to include intron sequences and the 3' and 5' untranslated regions in the alignments and also the inclusion of new genes such as MICA. The IMGT/MHC database (http://www.ebi.ac.uk/imgt/mhc) was released in March 2002 to provide a similar resource for other species. The first release of IMGT/MHC contains the sequences of non-human primates (apes, new and old world monkeys), canines and feline sequences. Further species will be added shortly and the database aims to become the primary source of MHC data for non-human sequences.

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