Nucleic Acids Research

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Nucleic Acids Research, 2003, Vol. 31, No. 1 315-318
© 2003 Oxford University Press

The InterPro Database, 2003 brings increased coverage and new features

Nicola J. Mulder^*,1, Rolf Apweiler¹, Teresa K. Attwood³, Amos Bairoch⁴, Daniel Barrell¹, Alex Bateman², David Binns¹, Margaret Biswas⁵, Paul Bradley^1,3, Peer Bork⁶, Phillip Bucher⁷, Richard R. Copley⁸, Emmanuel Courcelle⁹, Ujjwal Das¹, Richard Durbin², Laurent Falquet⁷, Wolfgang Fleischmann¹, Sam Griffiths-Jones², Daniel Haft¹⁰, Nicola Harte¹, Nicolas Hulo⁴, Daniel Kahn⁹, Alexander Kanapin¹, Maria Krestyaninova¹, Rodrigo Lopez¹, Ivica Letunic⁶, David Lonsdale¹, Ville Silventoinen¹, Sandra E. Orchard¹, Marco Pagni⁷, David Peyruc⁹, Chris P. Ponting¹¹, Jeremy D. Selengut¹⁰, Florence Servant¹, Christian J. A. Sigrist⁴, Robert Vaughan¹ and Evgueni M. Zdobnov^6,12

¹ EMBL Outstation—European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK ² Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK ³ School of Biological Sciences and Department of Computer Science, The University of Manchester, Manchester, UK ⁴ Swiss Institute for Bioinformatics, Geneva, Switzerland ⁵ ViaLactia Biosciences, Newmarket Auckland, New Zealand ⁶ Biocomputing Unit EMBL, Heidelberg, Germany ⁷ Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland ⁸ Wellcome Trust Centre for Human Genetics, Oxford, UK ⁹ CNRS/INRA, Toulouse, France ¹⁰ The Institute for Genomic Research, MD, USA ¹¹ MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, UK ¹² EMBL, Heidelberg, Germany

*To whom correspondence should be addressed. Tel: +44 1223 494602; Fax: +44 1223 494468; Email: mulder{at}ebi.ac.uk

ABSTRACT

InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a means of amalgamating the major protein signature databases into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the results that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modifications. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).

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