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Nucleic Acids Research, 2003, Vol. 31, No. 1 379-382
© 2003 Oxford University Press

Active Sequences Collection (ASC) database: a new tool to assign functions to protein sequences

Angelo M. Facchiano*, Antonio Facchiano1 and Francesco Facchiano1

Istituto di Scienze dell'Alimentazione, CNR—via Roma 52A/C 83100 Avellino, Italy 1 IDI, Istituto Dermopatico dell'Immacolata—via Monti di Creta 104, 00167 Roma, Italy

*To whom correspondence should be addressed. Email: angelo.facchiano{at}isa.av.cnr.it
The authors wish it to be known that, in their opinion, all three authors should be regarded as joint First Authors

ABSTRACT

Active Sequences Collection (ASC) is a collection of amino acid sequences, with an unique feature: only short sequences are collected, with a demonstrated biological activity. The current version of ASC consists of three sections: DORRS, a collection of active RGD-containing peptides; TRANSIT, a collection of protein regions active as substrates of transglutaminase enzyme (TGase), and BAC, a collection of short peptides with demonstrated biological activity. Literature references for each entry are reported, as well as cross references to other databases, when available. The current version of ASC includes more than 800 different entries. The main scope of this collection is to offer a new tool to investigate the structural features of protein active sites, additionally to similarity searches against large protein databases or searching for known functional patterns. ASC database is available at the web address http://crisceb.unina2.it/ASC/ which also offers a dedicated query interface to compare user-defined protein sequences with the database, as well as an updating interface to allow contribution of new referenced active sequences.


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