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Nucleic Acids Research, 2003, Vol. 31, No. 1 483-485
© 2003 Oxford University Press

NTDB: Thermodynamic Database for Nucleic Acids, Version 2.0

Wing Lok Abe Kurtz Chiu, Chun Ngai Sze, Nap Tak Ma, Lai Fan Chiu, Chung Wai Leung and Steve Chik Fun Au-Yeung*

Department of Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China

*To whom correspondence should be addressed. Tel: +852 26096257; Fax: +852 26035057; Email: scfau-yeung{at}cuhk.edu.hk

ABSTRACT

The second release of Thermodynamic Database for Nucleic Acids, NTDB 2.0, includes more than 4600 entries (250% increase over release 1.0). It contains sequence types and details of several thermodynamic parameters (enthalpy, {Delta}H; entropy, {Delta}S; Gibbs free energy, {Delta}G; melting temperature, Tm), experimental models and methods for extracting thermodynamic parameters, buffer conditions as well as all relevant literature information. In addition, the database statistics and references related to NTDB are included. Information on normal and modified nucleobases and nucleosides are collected in a new section ‘Nucleoside’ whereby data collected thus far will be release in NTDB 2.0. The NTDB is freely available at http://ntdb.chem.cuhk.edu.hk.


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