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Nucleic Acids Research, 2003, Vol. 31, No. 12 3114-3122
© 2003 Oxford University Press

The SV40 T antigen modulates CBP histone acetyltransferase activity

Ester Valls, Xavier de la Cruz1,2 and Marian A. Martínez-Balbás

Instituto de Biología Molecular de Barcelona, CID, Consejo Superior de Investigaciones Científicas (CSIC), Jordi Girona 18–26, E-08034 Barcelona, Spain, 1 Instituto Català per la Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys, 23, E-08018 Barcelona, Spain and 2 Molecular Modeling & Bioinformatics Unit, Parc Cientific de Barcelona, C/Josep Samitier, 1-5, 08028 Barcelona, Spain

*To whom correspondence should be addressed. Tel: +34 93 400 61 41; Fax: +34 93 204 59 04; Email: mmbbmc{at}ibmb.csic.es

Histone acetyltransferases (HATs) play a key role in transcription control, cell proliferation and differentiation by modulating chromatin structure; however, little is known about their own regulation. Here we show that expression of the viral oncoprotein SV40 T antigen increases histone acetylation and global cellular HAT activities. In addition, it enhances CREB-binding protein HAT activity and modulates its transcriptional activity. Finally, we show that inhibition of cellular histone deacetylases by trichostatin A increases the SV40 infectivity rate. These findings highlight the importance of histone acetylation in the regulation of the cell cycle by oncoviral proteins.


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