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Nucleic Acids Research, 2003, Vol. 31, No. 13 3400-3403
© 2003 Oxford University Press

NRSAS: Nuclear Receptor Structure Analysis Servers

Emmanuel Bettler, Roland Krause1, Florence Horn2 and Gert Vriend*

CMBI KUN, PO Box 9010, 6500 GL Nijmegen, The Netherlands 1 Washington University, Center for Computational Mechanics, Saint Louis, MO, USA 2 UCSF, Genentech Hall, 600 16th Street, San Francisco CA 94143-2240, USA

*To whom correspondence should be addressed. Tel: +31 24 36 53391; Fax: +31 24 36 52977; Email: vriend{at}cmbi.kun.nl

We present a coherent series of servers that can perform a large number of structure analyses on nuclear hormone receptors. These servers are part of the NucleaRDB project, which provides a powerful information system for nuclear hormone receptors. The computations performed by the servers include homology modelling, structure validation, calculating contacts, accessibility values, hydrogen bonding patterns, predicting mutations and a host of two- and three-dimensional visualisations. The Nuclear Receptor Structure Analysis Servers (NRSAS) are freely accessible at http://www.cmbi.kun.nl/NR/servers/html/ and in-house copies can be obtained upon request.


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