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Nucleic Acids Research, 2003, Vol. 31, No. 13 3525-3526
© 2003 Oxford University Press

MAVID multiple alignment server

Nicolas Bray and Lior Pachter*

Department of Mathematics, 970 Evans Hall, UC Berkeley, Berkeley, CA 94720, USA

*To whom correspondence should be addressed. Tel: +1 510 642 2028; Fax: +1 510 642 8204; Email: lpachter{at}math.berkeley.edu

MAVID is a multiple alignment program suitable for many large genomic regions. The MAVID web server allows biomedical researchers to quickly obtain multiple alignments for genomic sequences and to subsequently analyse the alignments for conserved regions. MAVID has been successfully used for the alignment of closely related species such as primates and also for the alignment of more distant organisms such as human and fugu. The server is fast, capable of aligning hundreds of kilobases in less than a minute. The multiple alignment is used to build a phylogenetic tree for the sequences, which is subsequently used as a basis for identifying conserved regions in the alignment. The server can be accessed at http://baboon.math.berkeley.edu/mavid/.


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