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Nucleic Acids Research, 2003, Vol. 31, No. 14 4119-4128
© 2003 Oxford University Press

Computational identification of non-coding RNAs in Saccharomyces cerevisiae by comparative genomics

John P. McCutcheon and Sean R. Eddy*

Howard Hughes Medical Institute and Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA

*To whom correspondence should be addressed. Tel: +1 314 362 7666; Fax: +1 314 362 7855; Email: eddy{at}genetics.wustl.edu
+AY253285–AY253289

We screened for new structural non-coding RNAs (ncRNAs) in the genome sequence of the yeast Saccharomyces cerevisiae using computational comparative analysis of genome sequences from five related species of Saccharomyces. The screen identified 92 candidate ncRNA genes. Thirteen showed discrete transcripts when assayed by northern blot. Of these, eight appear to be novel ncRNAs ranging in size from 268 to 775 nt, including three new H/ACA box small nucleolar RNAs.


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