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Nucleic Acids Research, 2003, Vol. 31, No. 5 1565-1570
© 2003 Oxford University Press

RNA sequences that work as transcriptional activating regions

Shamol Saha, Aseem Z. Ansari, Kevin A. Jarrell1 and Mark Ptashne*

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA and 1 Department of Pharmacology and Experimental Therapeutics, Boston University Medical Center, Boston, MA 02118, USA

*To whom correspondence should be addressed at Memorial Sloan Kettering Cancer Center, Box 595, 1275 York Avenue, New York, NY 10021, USA. Tel: +1 212 639 2297 or 5185; Fax: +1 212 717 3627; Email: m-ptashne{at}ski.mskcc.org
Present addresses:
Shamol Saha, Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA
Aseem Z. Ansari, Department of Biochemistry and The Genome Center, University of Wisconsin-Madison, Madison, WI 53706, USA
Mark Ptashne, Molecular Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA

We describe a set of RNA molecules that work as transcriptional activators when tethered to DNA. These RNA activating regions were found amongst a randomized set of molecules bearing variants of a 10 nt loop attached to an RNA stem. The various RNA activating regions all bear an identical five- residue sequence with an interspersed sixth residue. The result shows that although all natural activating regions characterized thus far are peptidic, this function can be served by other kinds of moieties as well.


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