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Nucleic Acids Research, 2003, Vol. 31, No. 7 1821-1829
© 2003 Oxford University Press

A structural and primary sequence comparison of the viral RNA-dependent RNA polymerases

Jeremy A. Bruenn

Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA and Hauptman Woodward Medical Research Institute, 73 High Street, Buffalo, NY 14203, USA

*To whom correspondence should be addressed at State University of New York, Buffalo, NY 14260, USA. Tel: +1 716 645 2363; Fax: +1 716 645 2975; Email: cambruen{at}nsm.buffalo.edu

A systematic bioinformatic approach to identifying the evolutionarily conserved regions of proteins has verified the universality of a newly described conserved motif in RNA-dependent RNA polymerases (motif F). In combination with structural comparisons, this approach has defined two regions that may be involved in unwinding double-stranded RNA (dsRNA) for transcription. One of these is the N-terminal portion of motif F and the second is a large insertion in motif F present in the RNA-dependent RNA polymerases of some dsRNA viruses.


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