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Nucleic Acids Research, 2003, Vol. 31, No. 7 1944-1954
© 2003 Oxford University Press

What’s in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence

Gertrud Mannhaupt1, Corinna Montrone2, Dirk Haase3, H. Werner Mewes1,2, Verena Aign4, Jörg D. Hoheisel4, Berthold Fartmann5, Gerald Nyakatura5, Frank Kempken6, Josef Maier7 and Ulrich Schulte8

1 Technical University of Munich, Department of Genome Oriented Bioinformatics, Freising-Weihenstephan, Germany, 2 GSF–National Research Center for Environment and Health, Institute for Bioinformatics (MIPS), Neuherberg, Germany, 3 University of Würzburg, Competence Center Pathogenomics, Würzburg, Germany, 4 Deutsches Krebsforschungszentrum, Functional Genome Analysis, Heidelberg, Germany, 5 MWG Biotech AG, Sequencing Department, Ebersberg, Germany, 6 Christian-Albrechts-Universität zu Kiel, Botanisches Institut, Kiel, Germany, 7 University of Tübingen, Institute of Plant Biochemistry, Tübingen, Germany and 8 Heinrich-Heine-University, Institute of Biochemistry, Dusseldorf, Germany

*To whom correspondence should be addressed. Tel: +49 2118112020; Fax: +49 2118115310; Email: ulrich.schulte{at}uni-duesseldorf.de

The German Neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively. Including additional sequences located on other linkage groups a total of 12 Mb were subjected to a manual gene extraction and annotation process. The genome comprises a small number of repetitive elements, a low degree of segmental duplications and very few paralogous genes. The analysis of the 3218 identified open reading frames provides a first overview of the protein equipment of a filamentous fungus. Significantly, N.crassa possesses a large variety of metabolic enzymes including a substantial number of enzymes involved in the degradation of complex substrates as well as secondary metabolism. While several of these enzymes are specific for filamentous fungi many are shared exclusively with prokaryotes.


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