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Nucleic Acids Research 2004 32(15):e121; doi:10.1093/nar/gnh120
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Published online 25 August 2004

Nucleic Acids Research, Vol. 32 No. 15 © Oxford University Press 2004; all rights reserved

Genomic representations using concatenates of Type IIB restriction endonuclease digestion fragments

Torstein Tengs1, Thomas LaFramboise2, Robert B. Den1, David N. Hayes1, Jianhua Zhang2, Saikat DebRoy2, Robert C. Gentleman2, Keith O'Neill3, Bruce Birren3 and Matthew Meyerson1,3,*

1 Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA, 2 Harvard School of Public Health, Department of Biostatistics, Boston, MA 02115, USA and 3 The Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA

* To whom correspondence should be addressed. Tel: +1 617 632 4768; Fax: +1 617 632 5998; Email: matthew_meyerson{at}dfci.harvard.edu

Received June 11, 2004; Revised and Accepted August 11, 2004

We have developed a method for genomic representation using Type IIB restriction endonucleases. Representation by concatenation of restriction digests, or RECORD, is an approach to sample the fragments generated by cleavage with these enzymes. Here, we show that the RECORD libraries may be used for digital karyotyping and for pathogen identification by computational subtraction.


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