Skip Navigation

Nucleic Acids Research 2004 32(21):6321-6326; doi:10.1093/nar/gkh973
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (396K) Freely available
Right arrow Supplementary Material
Right arrow Supplementary Material
Right arrow Supplementary Material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (15)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Doerks, T.
Right arrow Articles by Bork, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Doerks, T.
Right arrow Articles by Bork, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published online 1 December 2004

Nucleic Acids Research, Vol. 32 No. 21 © Oxford University Press 2004; all rights reserved

Functional clues for hypothetical proteins based on genomic context analysis in prokaryotes

Tobias Doerks*, Christian von Mering and Peer Bork

EMBL, 69012 Heidelberg, Meyerhofstrasse 1 and Max-Delbrueck-Centrum, Robert-Roessle-Strasse 10, D-13092 Berlin, Germany

* To whom correspondence should be addressed. Tel: +49 6221 387456; Fax: +49 6221 387517; Email: doerks{at}embl.de
Correspondence may also be addressed to Christian von Mering. Tel: +49 6221 387534; Fax: +49 6221 387517; Email: mering{at}embl.de

Received October 6, 2004; Revised and Accepted November 11, 2004

Three integrated genomic context methods were used to annotate uncharacterized proteins in 102 bacterial genomes. Of 7853 orthologous groups with unknown function containing 45 110 proteins, 1738 groups could be linked to functionally associated partners. In many cases, those partners are uncharacterized themselves (hinting at newly identified modules) or have been described in general terms only. However, we were able to assign pathways, cellular processes or physical complexes for 273 groups (encompassing 3624 previously functionally uncharacterized proteins).


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
P. Torija, J. J. Vicente, T. B. Rodrigues, A. Robles, S. Cerdan, L. Sastre, R. M. Calvo, and R. Escalante
Functional genomics in Dictyostelium: MidA, a new conserved protein, is required for mitochondrial function and development
J. Cell Sci., March 15, 2006; 119(6): 1154 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Vallenet, L. Labarre, Z. Rouy, V. Barbe, S. Bocs, S. Cruveiller, A. Lajus, G. Pascal, C. Scarpelli, and C. Medigue
MaGe: a microbial genome annotation system supported by synteny results
Nucleic Acids Res., January 10, 2006; 34(1): 53 - 65.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.