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Nucleic Acids Research 2004 32(22):6617-6626; doi:10.1093/nar/gkh996
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Published online 16 December 2004

Nucleic Acids Research, Vol. 32 No. 22 © Oxford University Press 2004; all rights reserved

Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics

Ivan Erill, Mónica Jara1, Noelia Salvador1, Marcos Escribano, Susana Campoy2 and Jordi Barbé1,2,*

Biomedical Applications Group, Centro Nacional de Microelectrónica, 08193 Bellaterra, Spain, 1 Departament de Genètica i Microbiologia, Universitat Autònoma de Barcelona 08193 Bellaterra, Spain and 2 Centre de Recerca en Sanitat Animal (CReSA), 08193 Bellaterra, Spain

* To whom correspondence should be addressed. Tel: +34 935811837; Fax: +34 935812387; Email: jordi.barbe{at}uab.es
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors

Received September 28, 2004; Revised November 2, 2004; Accepted November 24, 2004

The LexA regulon encompasses an ensemble of genes involved in preserving cell viability under massive DNA damage and is present in most bacterial phyla. Up to date, however, the scope of this network had only been assessed in the Gamma Proteobacteria. Here, we report the structure of the LexA regulon in the Alpha Proteobacteria, using a combined approach that makes use of in vitro and in vivo techniques to assist and validate the comparative genomics in silico methodology. This leads to the first experimentally validated description of the LexA regulon in the Alpha Proteobacteria, and comparison of regulon core structures in both classes suggests that a least common multiple set of genes (recA, ssb, uvrA and ruvCAB) might be a defining property of the Proteobacteria LexA network.


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