Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow Print PDF (275K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Dandekar, D. H.
Right arrow Articles by Mitra, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dandekar, D. H.
Right arrow Articles by Mitra, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published online 23 February 2004

Nucleic Acids Research, 2004, Vol. 32, No. 4 1270-1278
© 2004 Oxford University Press

HIV-1 Tat directly binds to NF{kappa}B enhancer sequence: role in viral and cellular gene expression

Dineshkumar H. Dandekar1,2, Krishna N. Ganesh1 and Debashis Mitra*,2

1 Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune-411008, India and 2 National Centre for Cell Science, Ganeshkhind, Pune-411007, India

*To whom correspondence should be addressed. Tel: +91 20 25690922/31; Fax: +91 20 25692259; Email: dmitra{at}nccs.res.in

HIV-1 Tat protein reprograms cellular gene expression of infected as well as uninfected cells apart from its primary function of transactivating HIV-1 long terminal repeat (LTR) promoter by binding to a nascent RNA stem–loop structure known as the transactivator response region (TAR). Tat also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting histone acetyl transferases to the chromatin, which results in histone acetylation. Furthermore several studies have shown convincing evidence that Tat can transactivate HIV-1 gene expression in the absence of TAR, the molecular mechanism of which remains to be elucidated. Here we show a direct interaction of Tat with nuclear factor kappa B (NF{kappa}B) enhancer, a global regulatory sequence for many cellular genes both in vitro and in vivo. This interaction not only provides a novel molecular basis to explain TAR-independent transactivation in HIV-1, but also points toward the potential mechanism of Tat- mediated modulation of cellular genes.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
P. K. Purbey, S. Singh, P. P. Kumar, S. Mehta, K. N. Ganesh, D. Mitra, and S. Galande
PDZ domain-mediated dimerization and homeodomain-directed specificity are required for high-affinity DNA binding by SATB1
Nucleic Acids Res., April 1, 2008; 36(7): 2107 - 2122.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
U. Mahlknecht, I. Dichamp, A. Varin, C. Van Lint, and G. Herbein
NF-{kappa}B-dependent control of HIV-1 transcription by the second coding exon of Tat in T cells
J. Leukoc. Biol., March 1, 2008; 83(3): 718 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
H. Muckenfuss, J. K. Kaiser, E. Krebil, M. Battenberg, C. Schwer, K. Cichutek, C. Munk, and E. Flory
Sp1 and Sp3 regulate basal transcription of the human APOBEC3G gene
Nucleic Acids Res., June 28, 2007; 35(11): 3784 - 3796.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
D. Kaniowska, R. Kaminski, S. Amini, S. Radhakrishnan, J. Rappaport, E. Johnson, K. Khalili, L. Del Valle, and A. Darbinyan
Cross-Interaction between JC Virus Agnoprotein and Human Immunodeficiency Virus Type 1 (HIV-1) Tat Modulates Transcription of the HIV-1 Long Terminal Repeat in Glial Cells.
J. Virol., September 1, 2006; 80(18): 9288 - 9299.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Sancho, L. de la Vega, A. Macho, G. Appendino, V. Di Marzo, and E. Munoz
Mechanisms of HIV-1 Inhibition by the Lipid Mediator N-Arachidonoyldopamine
J. Immunol., September 15, 2005; 175(6): 3990 - 3999.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.