Nucleic Acids Research, 2004, Vol. 32, Database issue D134-D137
© 2004 Oxford University Press
Recent improvements to the PROSITE database
Swiss Institute of Bioinformatics (SIB), CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland, 1 Swiss Institute of Bioinformatics (SIB), Biozentrum, University of Basel, Klingelbergstrasse 5070, CH-4056 Basel, Switzerland and 2 Swiss Institute of Bioinformatics (SIB), Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges/Lausanne, Switzerland
*To whom correspondence should be addressed. Tel: +41 21 379 58 72; Fax +41 21 379 58 58; Email: Nicolas.Hulo{at}isb-sib.ch
The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to documentation that provides useful biological information on the protein family, domain or functional site identified by the signature. The PROSITE web page has been redesigned and several tools have been implemented to help the user discover new conserved regions in their own proteins and to visualize domain arrangements. We also introduced the facility to search PDB with a PROSITE entry or a users pattern and visualize matched positions on 3D structures. The latest version of PROSITE (release 18.17 of November 30, 2003) contains 1676 entries. The database is accessible at http://www.expasy.org/prosite/.
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