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Nucleic Acids Research, 2004, Vol. 32, Database issue D134-D137
© 2004 Oxford University Press

Recent improvements to the PROSITE database

Nicolas Hulo*, Christian J. A. Sigrist, Virginie Le Saux, Petra S. Langendijk-Genevaux, Lorenza Bordoli1, Alexandre Gattiker, Edouard De Castro, Philipp Bucher2 and Amos Bairoch

Swiss Institute of Bioinformatics (SIB), CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland, 1 Swiss Institute of Bioinformatics (SIB), Biozentrum, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, Switzerland and 2 Swiss Institute of Bioinformatics (SIB), Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges/Lausanne, Switzerland

*To whom correspondence should be addressed. Tel: +41 21 379 58 72; Fax +41 21 379 58 58; Email: Nicolas.Hulo{at}isb-sib.ch

The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to documentation that provides useful biological information on the protein family, domain or functional site identified by the signature. The PROSITE web page has been redesigned and several tools have been implemented to help the user discover new conserved regions in their own proteins and to visualize domain arrangements. We also introduced the facility to search PDB with a PROSITE entry or a user’s pattern and visualize matched positions on 3D structures. The latest version of PROSITE (release 18.17 of November 30, 2003) contains 1676 entries. The database is accessible at http://www.expasy.org/prosite/.


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P. Stothard, G. Van Domselaar, S. Shrivastava, A. Guo, B. O'Neill, J. Cruz, M. Ellison, and D. S. Wishart
BacMap: an interactive picture atlas of annotated bacterial genomes
Nucleic Acids Res., January 1, 2005; 33(suppl_1): D317 - D320.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
W.-C. Kao, Y.-R. Chen, E. C. Yi, H. Lee, Q. Tian, K.-M. Wu, S.-F. Tsai, S. S.-F. Yu, Y.-J. Chen, R. Aebersold, et al.
Quantitative Proteomic Analysis of Metabolic Regulation by Copper Ions in Methylococcus capsulatus (Bath)
J. Biol. Chem., December 3, 2004; 279(49): 51554 - 51560.
[Abstract] [Full Text] [PDF]


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Appl. Environ. Microbiol.Home page
G. Rhodes, J. Parkhill, C. Bird, K. Ambrose, M. C. Jones, G. Huys, J. Swings, and R. W. Pickup
Complete Nucleotide Sequence of the Conjugative Tetracycline Resistance Plasmid pFBAOT6, a Member of a Group of IncU Plasmids with Global Ubiquity
Appl. Envir. Microbiol., December 1, 2004; 70(12): 7497 - 7510.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
M. Y. Galperin and E. V. Koonin
'Conserved hypothetical' proteins: prioritization of targets for experimental study
Nucleic Acids Res., October 12, 2004; 32(18): 5452 - 5463.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
N. Harte, V. Silventoinen, E. Quevillon, S. Robinson, K. Kallio, X. Fustero, P. Patel, P. Jokinen, and R. Lopez
Public web-based services from the European Bioinformatics Institute
Nucleic Acids Res., July 1, 2004; 32(suppl_2): W3 - W9.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
S. Rigali, M. Schlicht, P. Hoskisson, H. Nothaft, M. Merzbacher, B. Joris, and F. Titgemeyer
Extending the classification of bacterial transcription factors beyond the helix-turn-helix motif as an alternative approach to discover new cis/trans relationships
Nucleic Acids Res., June 24, 2004; 32(11): 3418 - 3426.
[Abstract] [Full Text] [PDF]


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Nucleic Acids ResHome page
R. Apweiler, A. Bairoch, C. H. Wu, W. C. Barker, B. Boeckmann, S. Ferro, E. Gasteiger, H. Huang, R. Lopez, M. Magrane, et al.
UniProt: the Universal Protein knowledgebase
Nucleic Acids Res., January 1, 2004; 32(90001): D115 - 119.
[Abstract] [Full Text] [PDF]



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