Nucleic Acids Research, 2004, Vol. 32, Database issue D142-D144
© 2004 Oxford University Press
SMART 4.0: towards genomic data integration
EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany, 1 Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK, 2 Bioinformatik, Biozentrum, Am Hubland, University of Wuerzburg, 97074 Wuerzburg, Germany and 3 MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
*To whom correspondence should be addressed. Tel: +49 6221 387 526; Fax: +49 6221 387 517; Email: bork{at}embl-heidelberg.de
SMART (Simple Modular Architecture Research Tool) is a web tool (http://smart.embl.de/) for the identification and annotation of protein domains, and provides a platform for the comparative study of complex domain architectures in genes and proteins. The January 2004 release of SMART contains 685 protein domains. New developments in SMART are centred on the integration of data from completed metazoan genomes. SMART now uses predicted proteins from complete genomes in its source sequence databases, and integrates these with predictions of orthology. New visualization tools have been developed to allow analysis of gene intronexon structure within the context of protein domain structure, and to align these displays to provide schematic comparisons of orthologous genes, or multiple transcripts from the same gene. Other improvements include the ability to query SMART by Gene Ontology terms, improved structure database searching and batch retrieval of multiple entries.
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K. Mazouni, G. Pehau-Arnaudet, P. England, P. Bourhy, I. Saint Girons, and M. Picardeau The Scc Spirochetal Coiled-Coil Protein Forms Helix-Like Filaments and Binds to Nucleic Acids Generating Nucleoprotein Structures J. Bacteriol., January 15, 2006; 188(2): 469 - 476. [Abstract] [Full Text] [PDF] |
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J. Boekhorst, Q. Helmer, M. Kleerebezem, and R. J. Siezen Comparative analysis of proteins with a mucus-binding domain found exclusively in lactic acid bacteria Microbiology, January 1, 2006; 152(1): 273 - 280. [Abstract] [Full Text] [PDF] |
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M. Y. Galperin The Molecular Biology Database Collection: 2006 update. Nucleic Acids Res., January 1, 2006; 34(Database issue): D3 - D5. [Abstract] [Full Text] [PDF] |
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N. L. Barbosa-Morais, M. Carmo-Fonseca, and S. Aparicio Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion Genome Res., January 1, 2006; 16(1): 66 - 77. [Abstract] [Full Text] [PDF] |
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V. Matys, O. V. Kel-Margoulis, E. Fricke, I. Liebich, S. Land, A. Barre-Dirrie, I. Reuter, D. Chekmenev, M. Krull, K. Hornischer, et al. TRANSFAC(R) and its module TRANSCompel(R): transcriptional gene regulation in eukaryotes Nucleic Acids Res., January 1, 2006; 34(suppl_1): D108 - D110. [Abstract] [Full Text] [PDF] |
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D. L. Wheeler, T. Barrett, D. A. Benson, S. H. Bryant, K. Canese, V. Chetvernin, D. M. Church, M. DiCuccio, R. Edgar, S. Federhen, et al. Database resources of the National Center for Biotechnology Information Nucleic Acids Res., January 1, 2006; 34(suppl_1): D173 - D180. [Abstract] [Full Text] [PDF] |
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A. K. L. Leung, L. Trinkle-Mulcahy, Y. W. Lam, J. S. Andersen, M. Mann, and A. I. Lamond NOPdb: Nucleolar Proteome Database Nucleic Acids Res., January 1, 2006; 34(suppl_1): D218 - D220. [Abstract] [Full Text] [PDF] |
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R. D. Finn, J. Mistry, B. Schuster-Bockler, S. Griffiths-Jones, V. Hollich, T. Lassmann, S. Moxon, M. Marshall, A. Khanna, R. Durbin, et al. Pfam: clans, web tools and services Nucleic Acids Res., January 1, 2006; 34(suppl_1): D247 - D251. [Abstract] [Full Text] [PDF] |
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I. Letunic, R. R. Copley, B. Pils, S. Pinkert, J. Schultz, and P. Bork SMART 5: domains in the context of genomes and networks Nucleic Acids Res., January 1, 2006; 34(suppl_1): D257 - D260. [Abstract] [Full Text] [PDF] |
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C. Yeats, M. Maibaum, R. Marsden, M. Dibley, D. Lee, S. Addou, and C. A. Orengo Gene3D: modelling protein structure, function and evolution Nucleic Acids Res., January 1, 2006; 34(suppl_1): D281 - D284. [Abstract] [Full Text] [PDF] |
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