Nucleic Acids Research, 2004, Vol. 32, Database issue D226-D229
© 2004 Oxford University Press
SCOP database in 2004: refinements integrate structure and sequence family data
MRC Centre for Protein Engineering and 3 MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK, 1 Department of Plant and Microbial Biology, 461A Koshland Hall 3102, University of California, Berkeley, CA 94720-3102, USA and 2 Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
*To whom correspondence should be addressed. Tel: +44 1223 402132; Fax: +44 1223 402140; Email: agm{at}mrc-lmb.cam.ac.uk
The Structural Classification of Proteins (SCOP) database is a comprehensive ordering of all proteins of known structure, according to their evolutionary and structural relationships. Protein domains in SCOP are hierarchically classified into families, superfamilies, folds and classes. The continual accumulation of sequence and structural data allows more rigorous analysis and provides important information for understanding the protein world and its evolutionary repertoire. SCOP participates in a project that aims to rationalize and integrate the data on proteins held in several sequence and structure databases. As part of this project, starting with release 1.63, we have initiated a refinement of the SCOP classification, which introduces a number of changes mostly at the levels below superfamily. The pending SCOP reclassification will be carried out gradually through a number of future releases. In addition to the expanded set of static links to external resources, available at the level of domain entries, we have started modernization of the interface capabilities of SCOP allowing more dynamic links with other databases. SCOP can be accessed at http://scop.mrc-lmb.cam.ac.uk/scop.
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