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Nucleic Acids Research, 2004, Vol. 32, Database issue D315-D318
© 2004 Oxford University Press

Génolevures: comparative genomics and molecular evolution of hemiascomycetous yeasts

David Sherman*, Pascal Durrens1, Emmanuelle Beyne, Macha Nikolski and Jean-Luc Souciet2 for the Génolevures Consortium

LaBRI, Laboratoire Bordelais de Recherche en Informatique, UMR CNRS 5800, 351 cours de la Libération, 33405 Talence cedex, France, 1 Centre de Bioinformatique de Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France and 2 Génétique et Microbiologie, FRE 2326 ULP/CNRS, GDR CNRS 2354, Institut de Botanique, 28 rue Goëthe, 67000 Strasbourg, France

*To whom correspondence should be addressed. Tel: +33 540 00 6922; Fax: +33 540 00 6669; Email: sherman{at}labri.fr
The Génolevures Consortium is coordinated by J. L. Souciet and is composed of laboratories from the Institut Pasteur (Paris), the INA-PG (Paris-Grignon), the Universities Bordeaux 1 and 2, Claude Bernard (Lyon), Paris-Sud (Orsay), Pierre et Marie Curie (Paris 6) and Louis Pasteur (Strasbourg), the Institut Curie (Paris), the Génoscope (Evry) and the Génopole Pasteur-Ile-de-France (Paris)

The Génolevures online database (http://cbi.labri.fr/Genolevures/) provides data and tools to facilitate comparative genomic studies on hemiascomycetous yeasts. Now, four complete genome sequences recently determined (Candida glabrata, Kluyveromyces lactis, Debaryomyces hansenii, Yarrowia lipolytica) have been added to the partial sequences of 13 species previously analysed by a random approach. The database also includes the reference genome Saccharomyces cerevisiae. Data are presented with a focus on relations between genes and genomes: conservation of genes and gene families, speciation, chromosomal reorganization and synteny. The Génolevures site includes a community area for specific studies by members of the international community.


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