Nucleic Acids Research, 2004, Vol. 32, Database issue D431-D433
© 2004 Oxford University Press
BRENDA, the enzyme database: updates and major new developments
University of Cologne, Institute of Biochemistry, Zülpicher Straße 47, 50674 Köln, Germany
*To whom correspondence should be addressed. Tel: +49 221 470 6440; Fax: +49 221 470 5092; Email: D.Schomburg{at}uni-koeln.de
The authors wish it to be known that, in their opinion, all authors should be regarded as joint First Authors
BRENDA (BRaunschweig ENzyme DAtabase) represents a comprehensive collection of enzyme and metabolic information, based on primary literature. The database contains data from at least 83 000 different enzymes from 9800 different organisms, classified in 
4200 EC numbers. BRENDA includes biochemical and molecular information on classification and nomenclature, reaction and specificity, functional parameters, occurrence, enzyme structure, application, engineering, stability, disease, isolation and preparation, links and literature references. The data are extracted and evaluated from 46 000 references, which are linked to PubMed as long as the reference is cited in PubMed. In the past year BRENDA has undergone major changes including a large increase in updating speed with >50% of all data updated in 2002 or in the first half of 2003, the development of a new EC-tree browser, a taxonomy-tree browser, a chemical substructure search engine for ligand structure, the development of controlled vocabulary, an ontology for some information fields and a thesaurus for ligand names. The database is accessible free of charge to the academic community at http://www.brenda. uni-koeln.de.
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