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Nucleic Acids Research, 2004, Vol. 32, Database issue D452-D455
© 2004 Oxford University Press

IntAct: an open source molecular interaction database

Henning Hermjakob*, Luisa Montecchi-Palazzi1, Chris Lewington, Sugath Mudali, Samuel Kerrien, Sandra Orchard, Martin Vingron2, Bernd Roechert3, Peter Roepstorff4, Alfonso Valencia5, Hanah Margalit6, John Armstrong7, Amos Bairoch3, Gianni Cesareni1, David Sherman8 and Rolf Apweiler

European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK, 1 Universita Tor Vergata, Rome, Italy, 2 Max Planck Institute for Molecular Genetics, Berlin, Germany, 3 Swiss Institute of Bioinformatics, Geneva, Switzerland, 4 University of Southern Denmark, Odense, Denmark, 5 National Center of Biotechnology, Madrid, Spain, 6 The Hebrew University of Jerusalem, Israel, 7 Glaxo Research and Development Limited, Stevenage, UK and 8 University of Bordeaux, France

*To whom correspondence should be addressed. Tel: +44 1223 494671; Fax: +44 1223 494468; Email: hhe{at}ebi.ac.uk

IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins. A web service allows direct computational access to retrieve interaction networks in XML format. IntAct currently contains ~2200 binary and complex interactions imported from the literature and curated in collaboration with the Swiss-Prot team, making intensive use of controlled vocabularies to ensure data consistency. All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact.


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