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Nucleic Acids Research, 2004, Vol. 32, Database issue D512-D515
© 2004 Oxford University Press

Pathbase: a database of mutant mouse pathology

Paul N. Schofield*, Jonathan B. L. Bard1, Catherine Booth2, Jacques Boniver3, Vincenzo Covelli4, Philippe Delvenne3, Michele Ellender5, Wilhelm Engstrom6, Wolfgang Goessner7, Michael Gruenberger, Heinz Hoefler7, John Hopewell8, Mariatheresa Mancuso4, Carmel Mothersill9, Christopher S. Potten2, Leticia Quintanilla-Fend7, Bjorn Rozell, Hannu Sariola11, John P. Sundberg12 and Andrew Ward13

Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK, 1 Department of Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh University, Edinburgh EH8 9XD, UK, 2 Paterson Institute, The Christie Hospital, Wilmslow Road, Manchester M20 4BX, UK and EpiStem Ltd, Incubator Building, Grafton Street, Manchester M13 9XX, UK, 3 Department of Pathology, University Hospital of Liege, B4000, Liege, Belgium, 4 ENEA, Divisione Protezione dell’uomo e degli Ecosistemi, Via Anguillarese 301, 00060, Rome, Italy, 5 National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK, 6 Department of Pathology, Swedish University of Agricultural Sciences, Uppsala 750 07, Sweden, 7 Institut fuer Pathologie, GSF-Forschungszentrum fuer Umwelt und Gesundheit, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany, 8 Department of Clinical Oncology, Churchill Hospital, Oxford OX3 7LJ, UK, 9 Radiation Science Centre, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland, 10 Clinical Research Center and Division of Pathology, IMPI, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden, 11 Institute of Biomedicine, Developmental Biology, PO Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Finland, 12 The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA and 13 Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK

*To whom correspondence should be addressed. Tel: +44 1223 333893; Fax: +44 1223 333754; Email: ps{at}mole.bio.cam.ac.uk

Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.


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