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Nucleic Acids Research, 2004, Vol. 32, Database issue D548-D551
© 2004 Oxford University Press

EICO (Expression-based Imprint Candidate Organizer): finding disease-related imprinted genes

Itoshi Nikaido1,2,3, Chika Saito3, Akiko Wakamoto3, Yasuhiro Tomaru3, Takahiro Arakawa3, Yoshihide Hayashizaki1,3 and Yasushi Okazaki*,2,3

1 Division of Genomic Information Resource Exploration, Science of Biological Supramolecular Systems, Yokohama City University, Graduate School of Integrated Science, Yokohama, Kanagawa 230-0045, Japan, 2 Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical School, Saitama 350-1241, Japan and 3 Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Yokohama, Kanagawa 230-0045, Japan

*To whom correspondence should be addressed at Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, 1397-1 Yamane, Hidaka City, Saitama 350-1241, Japan. Tel: +81 429 85 7319; Fax: +81 429 85 7329; Email: okazaki{at}saitama-med.ac.jp

We have developed an integrated database that is specialized for the study of imprinted disease genes. The database contains novel candidate imprinted genes identified by the RIKEN full-length mouse cDNA microarray study, information on validated single nucleotide polymorphisms (SNPs) to confirm imprinting using reciprocal mouse crosses and the predicted physical position of imprinting-related disease loci in the mouse and human genomes. It has two user-friendly search interfaces: the SNP-central view (MuSCAT: MoUse SNP CATalog) and the candidate gene-central view (CITE: Candidate Imprinted Transcripts by Expression). The database, EICO (Expression-based Imprint Candidate Organizer), can be accessed via the World Wide Web (http://fantom2.gsc.riken.jp/EICODB/) and the DAS client software. These data and interfaces facilitate understanding of the mechanism of imprinting in mammalian inherited traits.


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