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Nucleic Acids Research, 2004, Vol. 32, Database issue D586-D589
© 2004 Oxford University Press

ANTIMIC: a database of antimicrobial sequences

M. Brahmachary1,2, S. P. T. Krishnan1, J. L. Y. Koh1, A. M. Khan1, S. H. Seah1, T. W. Tan2, V. Brusic1,3 and V. B. Bajic*,1

1 Institute of Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613, 2 Department of Biochemistry, National University of Singapore, Singapore and 3 Department of Microbiology, National University of Singapore, Singapore

*To whom correspondence should be addressed. Tel: +65 6874 8800; Fax: +65 6774 8056; Email: bajicv{at}i2r.a-star.edu.sg

Antimicrobial peptides (AMPs) are important components of the innate immune system of many species. These peptides are found in eukaryotes, including mammals, amphibians, insects and plants, as well as in prokaryotes. Other than having pathogen-lytic properties, these peptides have other activities like antitumor activity, mitogen activity, or they may act as signaling molecules. Their short length, fast and efficient action against microbes and low toxicity to mammals have made them potential candidates as peptide drugs. In many cases they are effective against pathogens that are resistant to conventional antibiotics. They can serve as natural templates for the design of novel antimicrobial drugs. Although there are vast amounts of data on natural AMPs, they are not available through one central resource. We have developed a comprehensive database (ANTIMIC, http://research.i2r. a-star.edu.sg/Templar/DB/ANTIMIC/) of known and putative AMPs, which contains ~1700 of these peptides. The database is integrated with tools to facilitate efficient extraction of data and their analysis at molecular level, as well as search for new AMPs. These tools include BLAST, PDB structure viewer and the Antimic profile module.


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