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Nucleic Acids Research 2004 32(Web Server Issue):W512-W516; doi:10.1093/nar/gkh403
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© 2004, the authors
Nucleic Acids Research, Vol. 32, Web Server issue © Oxford University Press 2004; all rights reserved

iMolTalk: an interactive, internet-based protein structure analysis server

Alexander V. Diemand* and Holger Scheib1

University of Lausanne and Swiss Institute of Bioinformatics, Chemin des Boveresses 155, 1066 Epalinges s/Lausanne, Switzerland and 1 University of Geneva and Swiss Institute of Bioinformatics, Centre Médicale Universitaire, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland

* To whom correspondence should be addressed. Tel: +41 0 79 213 0571; Fax: +41 0 21 692 5945; Email: alexander.diemand{at}isb-sib.ch

Received February 14, 2004; Revised and Accepted March 29, 2004

iMolTalk (http://i.moltalk.org) is a new and interactive web server for protein structure analysis. It addresses the need to identify and highlight biochemically important regions in protein structures. As input, the server requires only the four-digit Protein Data Bank (PDB) identifier, of an experimentally determined structure or a structure file in PDB format stemming e.g. from comparative modelling. iMolTalk offers a wide range of implemented tools (i) to extract general information from PDB files, such as generic header information or the sequence derived from three-dimensional co-ordinates; (ii) to map corresponding residues from sequence to structure; (iii) to search for contacts of residues (amino or nucleic acids) or heterogeneous groups to the protein, present cofactors and substrates; and (iv) to identify protein–protein interfaces between chains in a structure. The server provides results as user-friendly two-dimensional graphical representations and in textual format, ideal for further processing. At any time during the analysis, the user can choose, for the following step, from the set of implemented tools or submit his/her own script to the server to extend the functionality of iMolTalk.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated.


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