Skip Navigation

Nucleic Acids Research 2005 33(14):4485-4495; doi:10.1093/nar/gki756
This Article
Right arrow Full Text Freely available
Right arrow Print PDF (2023K) Freely available
Right arrow Screen PDF (732K) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (26)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Piccinelli, P.
Right arrow Articles by Samuelsson, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Piccinelli, P.
Right arrow Articles by Samuelsson, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Published online 8 August 2005

© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

Identification and analysis of ribonuclease P and MRP RNA in a broad range of eukaryotes

Paul Piccinelli1, Magnus Alm Rosenblad1,2 and Tore Samuelsson1,*

1Department of Medical Biochemistry, Goteborg University Box 440, SE-405 30 Göteborg, Sweden 2SWEGENE Bioinformatics, Goteborg University Box 413, SE-405 30 Goteborg, Sweden

*To whom correspondence should be addressed. Tel: +46 31 773 34 68; Fax +46 31 41 61 08; Email: tore.samuelsson{at}medkem.gu.se

Received April 20, 2005. Revised June 3, 2005. Accepted July 21, 2005.

RNases P and MRP are ribonucleoprotein complexes involved in tRNA and rRNA processing, respectively. The RNA subunits of these two enzymes are structurally related to each other and play an essential role in the enzymatic reaction. Both of the RNAs have a highly conserved helical region, P4, which is important in the catalytic reaction. We have used a bioinformatics approach based on conserved elements to computationally analyze available genomic sequences of eukaryotic organisms and have identified a large number of novel nuclear RNase P and MRP RNA genes. For MRP RNA for instance, this investigation increases the number of known sequences by a factor of three. We present secondary structure models of many of the predicted RNAs. Although all sequences are able to fold into the consensus secondary structure of P and MRP RNAs, a striking variation in size is observed, ranging from a Nosema locustae MRP RNA of 160 nt to much larger RNAs, e.g. a Plasmodium knowlesi P RNA of 696 nt. The P and MRP RNA genes appear in tandem in some protists, further emphasizing the close evolutionary relationship of these RNAs.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 RNAHome page
P. Menzel, J. Gorodkin, and P. F. Stadler
The tedious task of finding homologous noncoding RNA genes
RNA, December 1, 2009; 15(12): 2075 - 2082.
[Abstract] [Full Text] [PDF]

Home page
 Gen Biol EvolHome page
X. Chen, L. J. Collins, P. J. Biggs, and D. Penny
High Throughput Genome-Wide Survey of Small RNAs from the Parasitic Protists Giardia intestinalis and Trichomonas vaginalis
Gen Biol Evol, July 24, 2009; 2009(0): 165 - 175.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
L. Lindahl, A. Bommankanti, X. Li, L. Hayden, A. Jones, M. Khan, T. Oni, and J. M. Zengel
RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway
RNA, July 1, 2009; 15(7): 1407 - 1416.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Hertel, D. de Jong, M. Marz, D. Rose, H. Tafer, A. Tanzer, B. Schierwater, and P. F. Stadler
Non-coding RNA annotation of the genome of Trichoplax adhaerens
Nucleic Acids Res., April 1, 2009; 37(5): 1602 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
A. R. Gruber, C. Kilgus, A. Mosig, I. L. Hofacker, W. Hennig, and P. F. Stadler
Arthropod 7SK RNA
Mol. Biol. Evol., September 1, 2008; 25(9): 1923 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
O. Esakova, A. Perederina, C. Quan, M. E. Schmitt, and A. S. Krasilnikov
Footprinting analysis demonstrates extensive similarity between eukaryotic RNase P and RNase MRP holoenzymes
RNA, August 1, 2008; 14(8): 1558 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
P. Larsson, A. Hinas, D. H. Ardell, L. A. Kirsebom, A. Virtanen, and F. Soderbom
De novo search for non-coding RNA genes in the AT-rich genome of Dictyostelium discoideum: Performance of Markov-dependent genome feature scoring
Genome Res., June 1, 2008; 18(6): 888 - 899.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
J. Hertel, I. L. Hofacker, and P. F. Stadler
SnoReport: computational identification of snoRNAs with unknown targets
Bioinformatics, January 15, 2008; 24(2): 158 - 164.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
S. Barth, B. Shalem, A. Hury, I. D. Tkacz, X.-h. Liang, S. Uliel, I. Myslyuk, T. Doniger, M. Salmon-Divon, R. Unger, et al.
Elucidating the Role of C/D snoRNA in rRNA Processing and Modification in Trypanosoma brucei
Eukaryot. Cell, January 1, 2008; 7(1): 86 - 101.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
K. Chakrabarti, M. Pearson, L. Grate, T. Sterne-Weiler, J. Deans, J. P. Donohue, and M. Ares Jr
Structural RNAs of known and unknown function identified in malaria parasites by comparative genomics and RNA analysis
RNA, November 1, 2007; 13(11): 1923 - 1939.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
A. Perederina, O. Esakova, H. Koc, M. E. Schmitt, and A. S. Krasilnikov
Specific binding of a Pop6/Pop7 heterodimer to the P3 stem of the yeast RNase MRP and RNase P RNAs
RNA, October 1, 2007; 13(10): 1648 - 1655.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
P. Piccinelli and T. Samuelsson
Evolution of the iron-responsive element
RNA, July 1, 2007; 13(7): 952 - 966.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y. Zhu, D. K. Pulukkunat, and Y. Li
Deciphering RNA structural diversity and systematic phylogeny from microbial metagenomes
Nucleic Acids Res., April 1, 2007; 35(7): 2283 - 2294.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
T. J.M. Welting, F. M.A. Peters, S. M.M. Hensen, N. L. van Doorn, B. J. Kikkert, J. M.H. Raats, W. J. van Venrooij, and G. J.M. Pruijn
Heterodimerization regulates RNase MRP/RNase P association, localization, and expression of Rpp20 and Rpp25
RNA, January 1, 2007; 13(1): 65 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
M. A. Rosenblad, M. D. Lopez, P. Piccinelli, and T. Samuelsson
Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes
Nucleic Acids Res., October 6, 2006; 34(18): 5145 - 5156.
[Abstract] [Full Text] [PDF]

Home page
 RNAHome page
Y. Zhu, V. Stribinskis, K. S. Ramos, and Y. Li
Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA
RNA, May 1, 2006; 12(5): 699 - 706.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
T. Gill, J. Aulds, and M. E. Schmitt
A specialized processing body that is temporally and asymmetrically regulated during the cell cycle in Saccharomyces cerevisiae
J. Cell Biol., April 10, 2006; 173(1): 35 - 45.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
S.R. EDDY
Computational Analysis of RNAs
Cold Spring Harb Symp Quant Biol, January 1, 2006; 71(0): 117 - 128.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
D.C. ZAPPULLA and T.R. CECH
RNA as a Flexible Scaffold for Proteins: Yeast Telomerase and Beyond
Cold Spring Harb Symp Quant Biol, January 1, 2006; 71(0): 217 - 224.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.