Published online 26 January 2005
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Noncoding DNA, isochores and gene expression: nucleosome formation potential
Institute of Cytology, Russian Academy of Sciences St Petersburg 194064, Russia
*Tel: +7 812 247 5310; Fax: +7 812 247 0341; Email: aevin{at}mail.cytspb.rssi.ru
Received October 5, 2004. Revised December 21, 2004. Accepted December 21, 2004.
The nucleosome formation potential of introns, intergenic spacers and exons of human genes is shown here to negatively correlate with among-tissues breadth of gene expression. The nucleosome formation potential is also found to negatively correlate with the GC content of genomic sequences; the slope of regression line is steeper in exons compared with noncoding DNA (introns and intergenic spacers). The correlation with GC content is independent of sequence length; in turn, the nucleosome formation potential of introns and intergenic spacers positively (albeit weakly) correlates with sequence length independently of GC content. These findings help explain the functional significance of the isochores (regions differing in GC content) in the human genome as a result of optimization of genomic structure for epigenetic complexity and support the notion that noncoding DNA is important for orderly chromatin condensation and chromatin-mediated suppression of tissue-specific genes.
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