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Nucleic Acids Research 2005 33(21):6816-6822; doi:10.1093/nar/gki988
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Published online 30 November 2005

© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

A study on the correlation of nucleotide skews and the positioning of the origin of replication: different modes of replication in bacterial species

Christoforos Nikolaou* and Yannis Almirantis

Institute of Biology, National Centre of Scientific Research ‘Demokritos’ 15310 Athens, Greece

*To whom correspondence should be addressed. Tel: +30 210 650 3618; Fax: +30 210 651 1767; Email: cnikol{at}bio.demokritos.gr

Received September 12, 2005. Revised October 20, 2005. Accepted November 14, 2005.

Deviations from Chargaff's 2nd parity rule, according to which A~T and G~C in single stranded DNA, have been associated with replication as well as with transcription in prokaryotes. Based on observations regarding mainly the transcription-replication co-linearity in a large number of prokaryotic species, we formulate the hypothesis that the replication procedure may follow different modes between genomes throughout which the skews clearly follow different patterns. We draw the conclusion that multiple functional sites of origin of replication may exist in the genomes of most archaea and in some exceptional cases of eubacteria, while in the majority of eubacteria, replication occurs through a single fixed origin.


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