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Nucleic Acids Research 2005 33(Database Issue):D131-D134; doi:10.1093/nar/gki136
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Nucleic Acids Research, 2005, Vol. 33, Database issue D131-D134
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

siRNAdb: a database of siRNA sequences

Alistair M. Chalk*, Richard E. Warfinge, Patrick Georgii-Hemming and Erik L. L. Sonnhammer

Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius väg 35, S-171 77 Stockholm, Sweden

* To whom correspondence should be addressed. Tel: +46 7 39824296; Fax: +46 8 337983; Email: alistair.chalk{at}cgb.ki.se
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors

Received August 15, 2004; Revised and Accepted October 28, 2004

Short interfering RNAs (siRNAs) are a popular method for gene-knockdown, acting by degrading the target mRNA. Before performing experiments it is invaluable to locate and evaluate previous knockdown experiments for the gene of interest. The siRNA database provides a gene-centric view of siRNA experimental data, including siRNAs of known efficacy and siRNAs predicted to be of high efficacy by a combination of methods. Linked to these sequences is information such as siRNA thermodynamic properties and the potential for sequence-specific off-target effects. The database enables the user to evaluate an siRNA's potential for inhibition and non-specific effects. The database is available at http://siRNA.cgb.ki.se.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact journals.permissions{at}oupjournals.org.


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