Nucleic Acids Research, 2005, Vol. 33, Database issue D174-D177
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved
TPMD: a database and resources of microsatellite marker genotyped in Taiwanese populations
1 Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 115, Taiwan, 2 Graduate Institute of Life Sciences, National Defense Medical Center, National Defense University, Taipei 114, Taiwan, 3 Department of Medical Research, Taichung Veterans General Hospital, Taichung 407, Taiwan, 4 Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan 701, Taiwan, 5 Department of Psychiatry and Institute of Human Genetics, Tzu-Chi University, Hualien 970, Taiwan and 6 Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan
* To whom correspondence should be addressed. Tel: +886 2 26524123; Fax: +886 2 27890484; Email: jou{at}nhri.org.tw
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors
Received August 13, 2004; Revised and Accepted October 14, 2004
Taiwan Polymorphic Marker Database (TPMD) (http://tpmd.nhri.org.tw/) is a marker database designed to provide experimental details and useful marker information allelotyped in Taiwanese populations accompanied by resources and technical supports. The current version deposited more than 372 000 allelotyping data from 1425 frequently used and fluorescent-labeled microsatellite markers with variation types of dinucleotide, trinucleotide and tetranucleotide. TPMD contains text and map displays with searchable and retrievable options for marker names, chromosomal location in various human genome maps and marker heterozygosity in populations of Taiwanese, Japanese and Caucasian. The integration of marker information in map display is useful for the selection of high heterozygosity and commonly used microsatellite markers to refine mapping of diseases locus followed by identification of disease gene by positional candidate cloning. In addition, our results indicated that the number of markers with heterozygosity over 0.7 in Asian populations is lower than that in Caucasian. To increase accuracy and facilitate genetic studies using microsatellite markers, we also list markers with genotyping difficulty due to ambiguity of allele calling and recommend an optimal set of microsatellite markers for genotyping in Taiwanese, and possible extension of genotyping in other Mongoloid populations.
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