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Nucleic Acids Research 2005 33(Database Issue):D325-D328; doi:10.1093/nar/gki008
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Nucleic Acids Research, 2005, Vol. 33, Database issue D325-D328
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

VFDB: a reference database for bacterial virulence factors

Lihong Chen, Jian Yang, Jun Yu1, Zhijian Yao2, Lilian Sun, Yan Shen2 and Qi Jin*

State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China, 1 The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK and 2 National Center of Human Genome Research, Beijing 100176, China

* To whom correspondence should be addressed. Tel: +86 10 6787 7732; Fax: +86 10 6787 7736; Email: zdsys{at}sina.com
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors

Received August 14, 2004; Revised and Accepted September 14, 2004

Bacterial pathogens continue to impose a major threat to public health worldwide in the 21st century. Intensified studies on bacterial pathogenesis have greatly expanded our knowledge about the mechanisms of the disease processes at the molecular level over the last decades. To facilitate future research, it becomes necessary to form a database collectively presenting the virulence factors (VFs) of various medical significant bacterial pathogens. The aim of virulence factor database (VFDB) (http://www.mgc.ac.cn/VFs/) is to provide such a source for scientists to rapidly access to current knowledge about VFs from various bacterial pathogens. VFDB is comprehensive and user-friendly. One can search VFDB by browsing each genus or by typing keywords. Furthermore, a BLAST search tool against all known VF-related genes is also available. VFDB provides a unified gateway to store, search, retrieve and update information about VFs from various bacterial pathogens.


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