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Nucleic Acids Research 2005 33(Database Issue):D329-D333; doi:10.1093/nar/gki028
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Nucleic Acids Research, 2005, Vol. 33, Database issue D329-D333
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

EchoBASE: an integrated post-genomic database for Escherichia coli

Raju V. Misra, Richard S. P. Horler, Wolfgang Reindl, Igor I. Goryanin1 and Gavin H. Thomas*

Department of Biology (Area 10), University of York, PO Box 373,York, YO10 5YW, UK and 1 Scientific Computing and Mathematical Modelling, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK

* To whom correspondence should be addressed. Tel: +44 1904 328678; Fax: +44 1904 328825; Email: ght2{at}york.ac.uk

Received August 13, 2004; Accepted September 21, 2004

EchoBASE (http://www.ecoli-york.org) is a relational database designed to contain and manipulate information from post-genomic experiments using the model bacterium Escherichia coli K-12. Its aim is to collate information from a wide range of sources to provide clues to the functions of the approximately 1500 gene products that have no confirmed cellular function. The database is built on an enhanced annotation of the updated genome sequence of strain MG1655 and the association of experimental data with the E.coli genes and their products. Experiments that can be held within EchoBASE include proteomics studies, microarray data, protein–protein interaction data, structural data and bioinformatics studies. EchoBASE also contains annotated information on ‘orphan’ enzyme activities from this microbe to aid characterization of the proteins that catalyse these elusive biochemical reactions.


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