Nucleic Acids Research, 2005, Vol. 33, Database issue D481-D484
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved
Polymorphix: a sequence polymorphism database
Laboratoire ‘Génome Populations Interactions Adaptation’, Unité Mixte de Recherche No. 5171 (UMR UM2–IFREMER–CNRS), Université de Montpellier 2, 34095 Montpellier Cedex 5, France and 1 Laboratoire de Biométrie et Biologie Evolutive, Unité Mixte de Recherche No. 5558 (UMR UCBL1–CNRS), Université Claude Bernard-Lyon 1, 69622 Villeurbanne Cedex, France
* To whom correspondence should be addressed. Tel: +33 467143913; Fax: +33 467144554; Email: bazin{at}univ-montp2.fr
Received August 5, 2004; Revised and Accepted October 8, 2004
Within-species sequence variation data are of special interest since they contain information about recent population/species history, and the molecular evolutionary forces currently in action in natural populations. These data, however, are presently dispersed within generalist databases, and are difficult to access. To solve this problem, we have developed Polymorphix, a database dedicated to sequence polymorphism. It contains within-species homologous sequence families built using EMBL/GenBank under suitable similarity and bibliographic criteria. Polymorphix is an ACNUC structured database allowing both simple and complex queries for population genomic studies. Alignments within families as well as phylogenetic trees can be download. When available, outgroups are included in the alignment. Polymorphix contains sequences from the nuclear, mitochondrial and chloroplastic genomes of every eukaryote species represented in EMBL. It can be accessed by a web interface (http://pbil.univ-lyon1.fr/polymorphix/query.php).
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