Nucleic Acids Research, 2005, Vol. 33, Database issue D501-D504
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Rm 6An.12J, 45 Center Drive, Bethesda, MD 20892-6510, USA
* To whom correspondence should be addressed. Tel: +1 301 435 5950; Fax: +1 301 480 2918; Email: pruitt{at}ncbi.nlm.nih.gov
Received September 15, 2004; Revised and Accepted September 21, 2004
The National Center for Biotechnology Information (NCBI) Reference Sequence (RefSeq) database (http://www.ncbi.nlm.nih.gov/RefSeq/) provides a non-redundant collection of sequences representing genomic data, transcripts and proteins. Although the goal is to provide a comprehensive dataset representing the complete sequence information for any given species, the database pragmatically includes sequence data that are currently publicly available in the archival databases. The database incorporates data from over 2400 organisms and includes over one million proteins representing significant taxonomic diversity spanning prokaryotes, eukaryotes and viruses. Nucleotide and protein sequences are explicitly linked, and the sequences are linked to other resources including the NCBI Map Viewer and Gene. Sequences are annotated to include coding regions, conserved domains, variation, references, names, database cross-references, and other features using a combined approach of collaboration and other input from the scientific community, automated annotation, propagation from GenBank and curation by NCBI staff.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact journals.permissions{at}oupjournals.org.
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J. Cao, J.-L. Li, D. Li, J. F. Tobin, and R. E. Gimeno Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis PNAS, December 26, 2006; 103(52): 19695 - 19700. [Abstract] [Full Text] [PDF] |
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E. Puerta-Fernandez, J. E. Barrick, A. Roth, and R. R. Breaker Identification of a large noncoding RNA in extremophilic eubacteria PNAS, December 19, 2006; 103(51): 19490 - 19495. [Abstract] [Full Text] [PDF] |
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J. Du, J. S. Rozowsky, J. O. Korbel, Z. D. Zhang, T. E. Royce, M. H. Schultz, M. Snyder, and M. Gerstein A supervised hidden markov model framework for efficiently segmenting tiling array data in transcriptional and chIP-chip experiments: systematically incorporating validated biological knowledge Bioinformatics, December 15, 2006; 22(24): 3016 - 3024. [Abstract] [Full Text] [PDF] |
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