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Nucleic Acids Research 2005 33(Database Issue):D511-D513; doi:10.1093/nar/gki061
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Nucleic Acids Research, 2005, Vol. 33, Database issue D511-D513
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

HCAD, closing the gap between breakpoints and genes

Robert Hoffmann*, Joaquin Dopazo1, Juan C. Cigudosa1 and Alfonso Valencia

National Center of Biotechnology, CNB-CSIC, Campus de la UAM, Cantoblanco, Madrid 28049, Spain and 1 Centro Nacional Investigaciones Oncologicas (CNIO), Melchor Fernández Almagro, 3, Madrid 28029, Spain

* To whom correspondence should be addressed. Tel: +34 91 5854570; Fax: +34 91 5854506; Email: hoffmann{at}cnb.uam.es
Correspondence may also be addressed to Alfonso Valencia. Tel: +34 91 5854570; Fax: +34 91 5854506; Email: valencia{at}cnb.uam.es

Received July 13, 2004; Revised and Accepted October 4, 2004

Recurrent chromosome aberrations are an important resource when associating human pathologies to specific genes. However, for technical reasons a large number of chromosome breakpoints are defined only at the level of cytobands and many of the genes involved remain unidentified. We developed a web-based information system that mines the scientific literature and generates textual and comprehensive information on all human breakpoints. We show that the statistical analysis of this textual information and its combination with genomic data can identify genes directly involved in DNA rearrangements. The Human Chromosome Aberration Database (HCAD) is publicly accessible at http://www.pdg.cnb.uam.es/UniPub/HCAD/.

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