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Nucleic Acids Research, 2005, Vol. 33, Database issue D54-D58
© 2005, the authors
Nucleic Acids Research, Vol. 33, Database issue © Oxford University Press 2005; all rights reserved

Entrez Gene: gene-centered information at NCBI

Donna Maglott*, Jim Ostell, Kim D. Pruitt and Tatiana Tatusova

National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Room 5AS.13B, 45 Center Drive, Bethesda, MD 20892-6510, USA

* To whom correspondence should be addressed. Tel: +1 301 435 5950; Fax: +1 301 480 2918; Email: maglott{at}ncbi.nlm.nih.gov

Received September 15, 2004; Accepted September 22, 2004

Entrez Gene (www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene) is NCBI's database for gene-specific information. It does not include all known or predicted genes; instead Entrez Gene focuses on the genomes that have been completely sequenced, that have an active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. The content of Entrez Gene represents the result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. Records are assigned unique, stable and tracked integers as identifiers. The content (nomenclature, map location, gene products and their attributes, markers, phenotypes, and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases) is updated as new information becomes available. Entrez Gene is a step forward from NCBI's LocusLink, with both a major increase in taxonomic scope and improved access through the many tools associated with NCBI Entrez.

The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use permissions, please contact journals.permissions{at}oupjournals.org.


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T. Wu, J. Wang, C. Liu, Y. Zhang, B. Shi, X. Zhu, Z. Zhang, G. Skogerbo, L. Chen, H. Lu, et al.
NPInter: the noncoding RNAs and protein related biomacromolecules interaction database
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D150 - D152.
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D. L. Wheeler, T. Barrett, D. A. Benson, S. H. Bryant, K. Canese, V. Chetvernin, D. M. Church, M. DiCuccio, R. Edgar, S. Federhen, et al.
Database resources of the National Center for Biotechnology Information
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D173 - D180.
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J. L. Fink, R. N. Aturaliya, M. J. Davis, F. Zhang, K. Hanson, M. S. Teasdale, C. Kai, J. Kawai, P. Carninci, Y. Hayashizaki, et al.
LOCATE: a mouse protein subcellular localization database
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D213 - D217.
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T. A. Eyre, F. Ducluzeau, T. P. Sneddon, S. Povey, E. A. Bruford, and M. J. Lush
The HUGO Gene Nomenclature Database, 2006 updates
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D319 - D321.
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G. R. Mishra, M. Suresh, K. Kumaran, N. Kannabiran, S. Suresh, P. Bala, K. Shivakumar, N. Anuradha, R. Reddy, T. M. Raghavan, et al.
Human protein reference database--2006 update
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D411 - D414.
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D. Cotter, A. Maer, C. Guda, B. Saunders, and S. Subramaniam
LMPD: LIPID MAPS proteome database
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D507 - D510.
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A. Ng, B. Bursteinas, Q. Gao, E. Mollison, and M. Zvelebil
pSTIING: a 'systems' approach towards integrating signalling pathways, interaction and transcriptional regulatory networks in inflammation and cancer
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D527 - D534.
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M. Krull, S. Pistor, N. Voss, A. Kel, I. Reuter, D. Kronenberg, H. Michael, K. Schwarzer, A. Potapov, C. Choi, et al.
TRANSPATH(R): an information resource for storing and visualizing signaling pathways and their pathological aberrations
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D546 - D551.
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B. R. Packer, M. Yeager, L. Burdett, R. Welch, M. Beerman, L. Qi, H. Sicotte, B. Staats, M. Acharya, A. Crenshaw, et al.
SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D617 - D621.
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H. Kawaji, T. Kasukawa, S. Fukuda, S. Katayama, C. Kai, J. Kawai, P. Carninci, and Y. Hayashizaki
CAGE Basic/Analysis Databases: the CAGE resource for comprehensive promoter analysis
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D632 - D636.
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A. S. Nord, P. J. Chang, B. R. Conklin, A. V. Cox, C. A. Harper, G. G. Hicks, C. C. Huang, S. J. Johns, M. Kawamoto, S. Liu, et al.
The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse
Nucleic Acids Res., January 1, 2006; 34(suppl_1): D642 - D648.
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