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TRAMPLE: the transmembrane protein labelling environment
Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna via Irnerio 42, I-40126 Bologna, Italy 1BioDec S.r.l., Almacube via Fanin 48, I-40127 Bologna, Italy
*To whom correspondence should be addressed. Tel: +39 051 2094005; Fax: +39 051 242576; Email: casadio{at}kaiser.alma.unibo.it
Received February 11, 2005. Revised March 30, 2005. Accepted March 30, 2005.
TRAMPLE (http://gpcr.biocomp.unibo.it/biodec/) is a web application server dedicated to the detection and the annotation of transmembrane protein sequences. TRAMPLE includes different state-of-the-art algorithms for the prediction of signal peptides, transmembrane segments (both beta-strands and alpha-helices), secondary structure and fast fold recognition. TRAMPLE also includes a complete content management system to manage the results of the predictions. Each user of the server has his/her own workplace, where the data can be stored, organized, accessed and annotated with documents through a simple web-based interface. In this manner, TRAMPLE significantly improves usability with respect to other more traditional web servers.
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