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MutDB services: interactive structural analysis of mutation data
Center for Computational Biology and Bioinformatics, Indiana University School of Medicine Indianapolis, IN 46202, USA 1Scientific Data Analysis Lab, Pervasive Technology Labs, Indiana University Indianapolis, IN 46202, USA
*To whom correspondence should be addressed. Tel: +1 317 278 9221; Fax: +1 317 278 9217; Email: sdmooney{at}iupui.edu
Received February 14, 2005. Revised March 21, 2005. Accepted March 21, 2005.
Non-synonymous single nucleotide polymorphisms (SNPs) and mutations have been associated with human phenotypes and disease. As more and more SNPs are mapped to phenotypes, understanding how these variations affect the function and expression of genes and gene products becomes an important endeavor. We have developed a set of tools to aid in the understanding of how amino acid substitutions affect protein structures. To do this, we have annotated SNPs in dbSNP and amino acid substitutions in Swiss-Prot with protein structural information, if available. We then developed a novel web interface to this data that allows for visualization of the location of these substitutions. We have also developed a web service interface to the dataset and developed interactive plugins for UCSF's Chimera structural modeling tool and PyMOL that integrate our annotations with these sophisticated structural visualization and modeling tools. The web services portal and plugins can be downloaded from http://www.lifescienceweb.org/ and the web interface is at http://www.mutdb.org/.
The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors
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