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Nucleic Acids Research 2005 33(Web Server Issue):W393-W396; doi:10.1093/nar/gki354
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© The Author 2005. Published by Oxford University Press. All rights reserved
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Article

TOUCAN 2: the all-inclusive open source workbench for regulatory sequence analysis

Stein Aerts1,2,*, Peter Van Loo2,3, Gert Thijs2, Herbert Mayer4, Rainer de Martin4, Yves Moreau2 and Bart De Moor2

1Laboratory of Neurogenetics, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology and K.U.Leuven Belgium 2Bioinformatics group, Department of Electrical Engineering ESAT-SCD, K.U.Leuven Belgium 3Human Genome Laboratory, Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology and K.U.Leuven Belgium 4Center for Biomolecular Medicine and Pharmacology, Department of Vascular Biology and Thrombosis Research, Medical University Vienna, and Biomolecular Therapeutics Vienna, Austria

*To whom correspondence should be addressed at Laboratory of Neurogenetics, Department of Human Genetics, Herestraat 49 bus 602, 3000 Leuven, Belgium. Tel: +32 16 347150; Fax: +32 16 346218; Email: stein.aerts{at}med.kuleuven.ac.be

Received November 12, 2004. Revised December 15, 2004. Accepted January 7, 2005.

We present the second and improved release of the TOUCAN workbench for cis-regulatory sequence analysis. TOUCAN implements and integrates fast state-of-the-art methods and strategies in gene regulation bioinformatics, including algorithms for comparative genomics and for the detection of cis-regulatory modules. This second release of TOUCAN has become open source and thereby carries the potential to evolve rapidly. The main goal of TOUCAN is to allow a user to come to testable hypotheses regarding the regulation of a gene or of a set of co-regulated genes. TOUCAN can be launched from this location: http://www.esat.kuleuven.ac.be/~saerts/software/toucan.php.


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