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Nucleic Acids Research 2005 33(Web Server Issue):W749-W752; doi:10.1093/nar/gki426
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© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

GenePath: from mutations to genetic networks and back

Peter Juvan1, Janez Demsar1, Gad Shaulsky2 and Blaz Zupan1,2,*

1Faculty of Computer and Information Science, University of Ljubljana Ljubljana, Slovenia 2Department of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA

*To whom correspondence should be addressed. Tel: +386 1 4768 402; Fax: +386 1 4768 386; Email: blaz.zupan{at}fri.uni-lj.si

Received February 14, 2005. Revised March 23, 2005. Accepted March 23, 2005.

GenePath is a web-based application for the analysis of mutant-based experiments and synthesis of genetic networks. Here, we introduce GenePath and describe a number of new approaches, including conflict resolution, handling cyclic pathways, confidence level assignment, what-if analysis and new experiment proposal. We illustrate the key concepts using data from a study of adhesion genes in Dictyostelium discoideum and show that GenePath discovered genetic interactions that were ignored in the original publication. GenePath is available at http://www.genepath.org/genepath2.


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