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Nucleic Acids Research 2005 33(Web Server Issue):W758-W761; doi:10.1093/nar/gki435
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© The Author 2005. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oupjournals.org

Article

GeneSeeker: extraction and integration of human disease-related information from web-based genetic databases

M. A. van Driel, K. Cuelenaere1, P. P. C. W. Kemmeren2, J. A. M. Leunissen1,3, H. G. Brunner4 and Gert Vriend*

Centre for Molecular and Biomolecular Informatics, Radboud University Nijmegen PO Box 9010, 6500GL Nijmegen, The Netherlands 1Dalicon BV PO Box 354, 6700AJ Wageningen, The Netherlands 2Genomics Laboratory, University Medical Centre Utrecht PO Box 85060, 3508AB Utrecht, The Netherlands 3Wageningen University and Research Centre Wageningen, The Netherlands 4Department of Human Genetics, University Medical Centre Nijmegen PO Box 9101, 6500HB Nijmegen, The Netherlands

*To whom correspondence should be addressed. Tel: +31 24 36 53391; Fax: +31 24 36 52977; Email: G.Vriend{at}cmbi.ru.al

Received February 12, 2005. Revised March 25, 2005. Accepted March 25, 2005.

The identification of genes underlying human genetic disorders requires the combination of data related to cytogenetic localization, phenotypes and expression patterns, to generate a list of candidate genes. In the field of human genetics, it is normal to perform this combination analysis by hand. We report on GeneSeeker (http://www.cmbi.ru.nl/GeneSeeker/), a web server that gathers and combines data from a series of databases. All database searches are performed via the web interfaces provided with the original databases, guaranteeing that the most recent data are queried, and obviating data warehousing. GeneSeeker makes the same selection of candidate genes as the human geneticists would have performed, and thus reducing the time-consuming process to a few minutes. GeneSeeker is particularly well suited for syndromes in which the disease gene displays altered expression patterns in the affected tissue(s).


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