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Nucleic Acids Research 2006 34(13):3670-3676; doi:10.1093/nar/gkl513
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Published online 2 August 2006

Nucleic Acids Research, 2006, Vol. 34, No. 13 3670-3676
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article

Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B–A transition in solution

Xi Li, Yinghua Peng and Xiaogang Qu*

Division of Biological Inorganic Chemistry, Key Laboratory of Rare Earth Chemistry and Physics, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun, Jilin 130022, China

*To whom correspondence should be addressed. Tel: 86 431 526 2656; Fax: 86 431 5262656; Email: xqu{at}ciac.jl.cn

Received May 5, 2006. Revised June 6, 2006. Accepted July 5, 2006.

Single-walled carbon nanotubes (SWNTs) have been considered as the leading candidate for nanodevice applications ranging from gene therapy and novel drug delivery to membrane separations. The miniaturization of DNA-nanotube devices for biological applications requires fully understanding DNA-nanotube interaction mechanism. We report here, for the first time, that DNA destabilization and conformational transition induced by SWNTs are sequence-dependent. Contrasting changes for SWNTs binding to poly[dGdC]:poly[dGdC] and poly[dAdT]:poly[dAdT] were observed. For GC homopolymer, DNA melting temperature was decreased 40°C by SWNTs but no change for AT-DNA. SWNTs can induce B–A transition for GC-DNA but AT-DNA resisted the transition. Our circular dichroism, competitive binding assay and triplex destabilization studies provide direct evidence that SWNTs induce DNA B–A transition in solution and they bind to the DNA major groove with GC preference.


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