Nucleic Acids Research Advance Access originally published online on August 26, 2006
Nucleic Acids Research 2006 34(15):4168-4180; doi:10.1093/nar/gkl468
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Nucleic Acids Research, 2006, Vol. 34, No. 15 4168-4180
© 2006 The Author(s)
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Survey and Summary |
Dead-box proteins: a family affair—active and passive players in RNP-remodeling
Department of Microbiology and Molecular Medicine, CMU 1, rue Michel Servet, CH-1211 Genève 4, Switzerland
Tel: +41 22 379 54 84; Fax: +41 22 379 55 02; Email: patrick.linder{at}medecine.unige.ch
Received May 3, 2006. Revised June 19, 2006. Accepted June 20, 2006.
DEAD-box proteins are characterized by nine conserved motifs. According to these criteria, several hundreds of these proteins can be identified in databases. Many different DEAD-box proteins can be found in eukaryotes, whereas prokaryotes have small numbers of different DEAD-box proteins. DEAD-box proteins play important roles in RNA metabolism, and they are very specific and cannot mutually be replaced. In vitro, many DEAD-box proteins have been shown to have RNA-dependent ATPase and ATP-dependent RNA helicase activities. From the genetic and biochemical data obtained mainly in yeast, it has become clear that these proteins play important roles in remodeling RNP complexes in a temporally controlled fashion. Here, I shall give a general overview of the DEAD-box protein family.
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