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Nucleic Acids Research 2006 34(9):2653-2662; doi:10.1093/nar/gkl338
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Published online 19 May 2006

© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

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The tale beyond the tail: histone core domain modifications and the regulation of chromatin structure

Erica L. Mersfelder and Mark R. Parthun*

Department of Molecular and Cellular Biochemistry, The Ohio State University Columbus, OH 43210, USA

*To whom correspondence should be addressed. Tel: +1 614 292 6215; Fax: +1 614 292 4118; Email: parthun.1{at}osu.edu

Received March 23, 2006. Revised April 12, 2006. Accepted April 17, 2006.

Histone post-translational modifications occur, not only in the N-terminal tail domains, but also in the core domains. While modifications in the N-terminal tail function largely through the regulation of the binding of non-histone proteins to chromatin, based on their location in the nucleosome, core domain modifications may also function through distinct mechanisms involving structural alterations to the nucleosome. This article reviews the recent developments in regards to these novel histone modifications and discusses their important role in the regulation of chromatin structure.


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