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Nucleic Acids Research 2006 34(Database Issue):D25-D28; doi:10.1093/nar/gkj009
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Nucleic Acids Research, 2006, Vol. 34, Database issue D25-D28
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

HUMHOT: a database of human meiotic recombination hot spots

K. T. Nishant1, Chetan Kumar2 and M. R. S. Rao1,2,*

1Department of Biochemistry, Indian Institute of Science Bangalore 560012, India 2Jawaharlal Nehru Center for Advanced Scientific Research Jakkur, Bangalore 560064, India

*To whom correspondence should be addressed. Tel: +91 80 22082865; Fax: +91 80 23622766; Email: mrsrao{at}jncasr.ac.in

Received July 29, 2005. Revised September 2, 2005. Accepted September 12, 2005.

Meiotic recombination occurs preferentially at certain regions in the genome referred to as hot spots. The number of hot spots known in humans has increased manifold in recent years. The identification of these hot spots in humans is of great interest to population and medical geneticists since they influence the structure of Linkage Disequilibrium and Haplotype blocks in human populations, whose patterns have applications in mapping disease genes. HUMHOT is a web-based database of Human Meiotic Recombination Hot Spots. The database comprises DNA sequences corresponding to the hot spot regions from the literature that have been mapped to a high resolution (<4 kb) in humans. It also provides flanking sequence information for the hot spot region along with references describing the hot spot. The database can be queried based on hot spot identity, chromosome position or by homology to user-defined sequences. It is also updated with new hot spot sequences as they are discovered and provides hyperlinks to commonly used tools for estimating recombination rates, performing genetic analysis and new advances in our understanding of meiotic hot spots. Public access to the HUMHOT database is available at http://www.jncasr.ac.in/humhot.

Correspondence may also be addressed to K. T. Nishant. Tel: +91 80 22932547; Fax: +91 80 23600118; Email: knis{at}biochem.iisc.ernet.in

The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors


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