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Nucleic Acids Research 2006 34(Database Issue):D267-D269; doi:10.1093/nar/gkj104
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Nucleic Acids Research, 2006, Vol. 34, Database issue D267-D269
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

LGICdb: a manually curated sequence database after the genomes

Marco Donizelli, Marie-Ange Djite and Nicolas Le Novère*

European Bioinformatics Institute, EMBL Wellcome-Trust Genome Campus, Hinxton CB10 1SD, UK

*To whom correspondence should be addressed. Tel: +44 1223 494521; Fax: +44 1223 494468; Email: lenov{at}ebi.ac.uk

Received September 14, 2005. Revised October 17, 2005. Accepted October 17, 2005.

Ligand-gated ion channels form transmembrane ionic pores controlled by the binding of chemicals. The LGICdb aims to be a non-redundant, manually curated resource offering access to the large number of subunits composing extracellularly activated ligand-gated ion channels, such as nicotinic, ATP, GABA and glutamate ionotropic receptors. Composed of more than 500 human curated entries, the XML native database has been relocated in 2004 to the EBI. Its facilities have been enhanced with a new search system, customized multiple sequence alignments and manipulation of protein structures (http://www.ebi.ac.uk/compneur-srv/LGICdb/). Despite the vast improvement of general sequence resources, the LGICdb still provide sequences unavailable elsewhere.


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