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Nucleic Acids Research 2006 34(Database Issue):D411-D414; doi:10.1093/nar/gkj141
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Nucleic Acids Research, 2006, Vol. 34, Database issue D411-D414
© The Author 2006. Published by Oxford University Press. All rights reserved
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Article

Human protein reference database—2006 update

Gopa R. Mishra1, M. Suresh1, K. Kumaran1, N. Kannabiran1, Shubha Suresh1, P. Bala1, K. Shivakumar1, N. Anuradha1, Raghunath Reddy1, T. Madhan Raghavan1, Shalini Menon1, G. Hanumanthu1, Malvika Gupta1, Sapna Upendran1, Shweta Gupta1, M. Mahesh1, Bincy Jacob1, Pinky Mathew1, Pritam Chatterjee1, K. S. Arun1, Salil Sharma1, K. N. Chandrika1, Nandan Deshpande1, Kshitish Palvankar1, R. Raghavnath1, R. Krishnakanth1, Hiren Karathia1, B. Rekha1, Rashmi Nayak1, G. Vishnupriya1, H. G. Mohan Kumar1, M. Nagini1, G. S. Sameer Kumar1, Rojan Jose1, P. Deepthi1, S. Sujatha Mohan1, T. K. B. Gandhi1, H. C. Harsha1, Krishna S. Deshpande1, Malabika Sarker1, T. S. Keshava Prasad1 and Akhilesh Pandey2,3,4,*

1Institute of Bioinformatics, International Tech Park Bangalore 560 066, India 2McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University Baltimore, MD 21205, USA 3Department of Biological Chemistry, Johns Hopkins University Baltimore, MD 21205, USA 4Department of Oncology, Johns Hopkins University Baltimore, MD 21205, USA

*To whom correspondence should be addressed at McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, 733 N. Broadway, BRB Room 569, Baltimore, MD 21205, USA. Tel: +1 410 502 6662; Fax: +1 410 502 7544; Email: pandey{at}jhmi.edu

Received September 15, 2005. Revised October 27, 2005. Accepted October 27, 2005.

Human Protein Reference Database (HPRD) (http://www.hprd.org) was developed to serve as a comprehensive collection of protein features, post-translational modifications (PTMs) and protein–protein interactions. Since the original report, this database has increased to >20 000 proteins entries and has become the largest database for literature-derived protein–protein interactions (>30 000) and PTMs (>8000) for human proteins. We have also introduced several new features in HPRD including: (i) protein isoforms, (ii) enhanced search options, (iii) linking of pathway annotations and (iv) integration of a novel browser, GenProt Viewer (http://www.genprot.org), developed by us that allows integration of genomic and proteomic information. With the continued support and active participation by the biomedical community, we expect HPRD to become a unique source of curated information for the human proteome and spur biomedical discoveries based on integration of genomic, transcriptomic and proteomic data.


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