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Nucleic Acids Research 2006 34(Database Issue):D415-D418; doi:10.1093/nar/gkj139
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Nucleic Acids Research, 2006, Vol. 34, Database issue D415-D418
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

The LIFEdb database in 2006

Alexander Mehrle*, Heiko Rosenfelder, Ingo Schupp, Coral del Val1, Dorit Arlt, Florian Hahne, Stephanie Bechtel, Jeremy Simpson2, Oliver Hofmann3, Winston Hide3, Karl-Heinz Glatting1, Wolfgang Huber4, Rainer Pepperkok2, Annemarie Poustka and Stefan Wiemann

Division Molecular Genome Analysis, German Cancer Research Center Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany 1Division Molecular Biophysics, German Cancer Research Center Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany 2European Molecular Biology Laboratory, Cell Biology and Biophysics Programme Meyerhofstrasse 1, D-69117 Heidelberg, Germany 3South African National Bioinformatics Institute, Old Chemistry Building, University of the Western Cape Bellville 7535, South Africa 4European Bioinformatics Institute Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK

*To whom correspondence should be addressed. Tel: +49 6221 42 3458; Fax: +49 6221 42 3454; Email: a.mehrle{at}dkfz.de

Received September 14, 2005. Revised October 19, 2005. Accepted October 27, 2005.

LIFEdb (http://www.LIFEdb.de) integrates data from large-scale functional genomics assays and manual cDNA annotation with bioinformatics gene expression and protein analysis. New features of LIFEdb include (i) an updated user interface with enhanced query capabilities, (ii) a configurable output table and the option to download search results in XML, (iii) the integration of data from cell-based screening assays addressing the influence of protein-overexpression on cell proliferation and (iv) the display of the relative expression (‘Electronic Northern’) of the genes under investigation using curated gene expression ontology information. LIFEdb enables researchers to systematically select and characterize genes and proteins of interest, and presents data and information via its user-friendly web-based interface.


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