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Nucleic Acids Research 2006 34(Database Issue):D586-D589; doi:10.1093/nar/gkj027
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Nucleic Acids Research, 2006, Vol. 34, Database issue D586-D589
© The Author 2006. Published by Oxford University Press. All rights reserved
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions{at}oxfordjournals.org

Article

QTL MatchMaker: a multi-species quantitative trait loci (QTL) database and query system for annotation of genes and QTL

Kremena V. Star1,2,*, Quingbin Song2, Andy Zhu2 and Erwin P. Böttinger2,*

1Albert Einstein College of Medicine One Gustave L. Levy Place, Box 1243, New York, NY 10029, USA 2Mount Sinai School of Medicine One Gustave L. Levy Place, Box 1243, New York, NY 10029, USA

*To whom correspondence should be addressed. Tel: +1 212 241 1884; Fax: +1 212 849 2643; Email: kvstar{at}aecom.yu.edu

Received August 11, 2005. Revised September 22, 2005. Accepted September 22, 2005.

Identifying genes that underlie quantitative trait loci (QTL) is a challenging task. Here, we present a new QTL software system, named QTL MatchMaker. The system is designed to integrate and mine QTL information across human, mouse and rat genomes and to annotate functional genomic data. It combines and organizes information from relevant public databases and publications and integrates QTL, physical, genetic and cytogenetic maps across human, mouse and rat. To make this application available to the research community we have developed a website for high-throughput mapping of expressed sequences to QTL and for selection of candidate genes in the physiological genomics context of complex traits. QTL MatchMaker is accessible at http://pmrc.med.mssm.edu:9090/QTL/jsp/qtlhome.jsp

Correspondence may also be addressed to Erwin P. Böttinger. Tel: +1 212 241 0800; Fax: +1 212 849 2643; Email: erwin.bottinger{at}mssm.edu


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